NAD+ Optimization with Dr. Jin-Xiong She
Today I am speaking with Dr. Jin-Xiong She about all thing NAD+, we discuss what it is, how to measure your NAD+ levels, what impact your NAD+ levels have on your health and longevity, how to optimize your NAD+ levels and so much more!
Use code KAYLA to save on all NAD+ optimization products !
About Dr. Dr. Jin-Xiong She
Dr. Jin-Xiong She received his college education in China and PhD degree in France. After a short postdoctoral training at the University of Florida (UF), he was quickly promoted to Assistant Professor, Associate Professor, Full and Endowed Professor. He served as Division Chief of Experimental Pathology and Director of Research of the UF’s world-class Diabetes Center. Dr. She was recruited in 2002 to be the Georgia Research Alliance Eminent Scholar in Genomic Medicine at the Medical College of Georgia. He was the founding Director of the Center for Biotechnology and Genomic Medicine, Professor of the Departments of Obstetrics and Gynecology and Department of Health Technologies as well as the director of two core research facilities for Augusta University (Genomics, Proteomics & Mass Spectrometry). In his long academic career, he has authored over 400-peer reviewed papers with an H-Index of 76 and over 19,000 citations, secured over $100 million in research grants, has been invited to speak globally. He mentored a large number of doctoral students, post-docs and faculty members. Dr. She is one of the 20 “Georgia Top Medical Researchers”. He served as President of the Chinese Geneticists in America and President of the American Diabetes Association’s council on Immunology, transplantation and Immunogenetics among other honors. Dr. She is a serial entrepreneur and has founded or co-founded multiple companies in the US and China. He is the founder and CEO of Jinfiniti Precision Medicine, a company dedicated to optimizing healthspan through biomarker testing and precision nutraceuticals. More information can be found on Jin-Xiong She’ LinkedIn Profile and Jin-Xiong She’s Google Scholar Profile. Boying DunPhD, co-Founder & Chief Innovation OfficerBob ThordarsonChief Technology OfficerMichael HeckPhD, CLIA Clinical Laboratory Director
[00:00:00.360] - Kayla Barnes-Lentz
Doctor, it is a pleasure to have you here with me today.
[00:00:03.290] - Dr. Jin-Xiong She
Yeah, it's my pleasure to join you.
[00:00:06.770] - Kayla Barnes-Lentz
Absolutely. So today we're going to be talking all things NAD optimization.
[00:00:12.530] - Dr. Jin-Xiong She
Yep. We can talk about NAD optimization, or we can talk about longevity in general.
[00:00:20.570] - Kayla Barnes-Lentz
I love that. Well, we know NAD plays a big role in longevity, so let's start there. Very basic. What is NAD?
[00:00:31.280] - Dr. Jin-Xiong She
All right, so NAD is a coenzyme. A coenzyme is a molecule that helps other enzymes to function. That's why it's called a coenzyme. A coenzyme, in some cases, like NAD, is required for the function of over 500 other enzymes. That's why they are so important, and they can impact the cellular processes in almost every part of the body. And the most important function of NAD is to help our cells to produce cellular energy in the form of ATP. Without ATP, we cannot survive, and without Nad, we cannot produce ATP. That's the number one function. But I can sit here and talk about 500 or more other functions that NAD has.
[00:01:38.310] - Kayla Barnes-Lentz
So, basically super important in energy production, right? So that's why a lot of times, I think when we see NAD advertised, there is a whole list of things that it can help with, right, from brain fog to energy. What would you say are maybe the top, like, five impacts that NAD can make? So maybe like brain health, how do you see it?
[00:02:05.240] - Dr. Jin-Xiong She
We can put it in two different ways. One, we can talk about the impact of NAD on biochemical or molecular functions, and we can also talk about in terms of what symptoms or pathologies energy deficiency can cause. Let's go through the biochemical functions first. Biochemical production of ATP. Number one, reduction for inflammation. Number two, reduction of oxidative stress. Number three, reduction of cellular senescence. Number four, recognition of metabolic function like insulin resistance and regulation of liver enzymes, and so on. So these are the top five functions, I might add, that it's very important for nurgic reactions, and so it's a very important immune regulator. From the symptom, medical point of view, the number one symptoms that we may see, if only this diffusion, is the lack of energy, or we can get tired very easily. And that's often seen by many people. Actually, about 70% of patients who go see a doctor complain about being tired all the time. And that's number one. The second one is brain function or neurological conditions. Brain fog, park, Parkinson's, Alzheimer's, autism, and they can all be related to NAD deficiency. And the next one is, you know, diabetes, obesity, or metabolic syndromes.
[00:04:18.110] - Dr. Jin-Xiong She
And the fourth one is allergy, asthma, and the fifth one that's very common is arthritis, inflammation, pain. You know, and I, you know, I can go on and on. Yeah. That's almost nothing that's not related to energy function. What we're finding even more now is the number one risk factor for heart failure is actually energy deficiency and associating energy production defect and mitochondrial dysfunction. Wow. Yeah. We also see ethnicity association. We don't know whether it's causal or not, but we. Ethnic association of energy Deficiency and Infertility. I mean, it's very new data. I wouldn't be surprised that war most, or major pathologies or diseases can have a contribution from NAD deficiency.
[00:05:37.560] - Kayla Barnes-Lentz
Wow. Well, I really specialize in female health, and I have a large female audience, so I would love to kind of lean into. I know it's very new, but what are you thinking is kind of the mechanism there in terms of any deficiency and fertility issues?
[00:05:55.550] - Dr. Jin-Xiong She
Yeah. So we know in women with infertility issues, inflammation is increased in the ovary, as particularly in an enzyme called CD 38. CD 38 eats NAD for lunch and dinner, and breakfast is a major NAD degrading enzyme. So that's why NAD levels in the ovaries in women with infertility issues are particularly low. And for now, it's association. I mean, no one has proven that NAD deficiency causes infertility issues yet, but I wouldn't be surprised that NAD supplementation or NAD optimization can help women with infertility issues. I would love to work with you and your members to do a study and see how NISA can help them on the male side. There's no data yet, but I'm very confident that the quantity and the quantity of sperms can be related to NAD as well. So this whole infertility issues may have a very strong relationship with NAD, and getting led optimized can make their body function better, and in particular, may increase sperm quality and quantity, increase the quality of oocyte and eggs, and make some infertility issues go away. I mean, there are some other ways that we can help beyond NAd, like inflammation, how we can reduce inflammation, how we can reduce oxidative stress, that can help infertility issues.
[00:08:07.570] - Dr. Jin-Xiong She
But NAD is definitely one of the top COVID issues we'll have to fix.
[00:08:12.790] - Kayla Barnes-Lentz
Well, I love that. And let's certainly talk about doing a study. This is actually something I'm very passionate about is getting more studies on women. Right. And human studies. So I would love to discuss that further. I think it's super interesting, and we need that data. So, for me, it's really exciting because I just did a full fertility workup. I've been measuring thousands of biomarkers for years now, but went through actual fertility and my fertility is in the top 90 plus percent, which is amazing. But with that being said, I have done NAd in a variety of different forms over the years. When I first learned about it, maybe eight years ago, I started with just some NR supplementation. I've done NMN. My clinic does my v therapy, which I'm excited to dive into because I know that the, the consensus around IV nad is, is changing a bit these days. But yeah, I've definitely now, now I'm taking your product. So, um, I love it. I'm doing it twice a day, which is amazing. It's super easy. I'm just putting it in water, mixing it up with some of my other longevity concoctions. But no, I would love to do that and that's super exciting.
[00:09:31.280] - Kayla Barnes-Lentz
And, and I appreciate your offer. So thank you.
[00:09:34.370] - Dr. Jin-Xiong She
Sure, my pleasure. So, I mean, I think more and more people are recognizing the importance of NAd, and they may have started using various NAD, either supplementation or iv or injections. But what everyone has to understand is that we are all different and we may need a different dosage of supplements to get our led optimized. Most experts or general public, they only talk about increasing energy levels. That's not good enough to me because I talk about led optimization. I know you talk about health optimization. I mean, you know, I do health optimization as well. But just like health optimization, your NAD optimization is part of the health optimization. It's absolutely essential to be able to test leading levels, especially after any kind of treatment. Ideally, you want to have a before treatment test, so you know your baseline level or your current level, and then after any kind of treatment, you know how well it has worked. And I can tell you, based on our recommendation, I believe our supplement is the best form to optimize led. But even with our supplement at the initial recommendation, we can only get led optimized for about 70% of the customers.
[00:11:34.420] - Dr. Jin-Xiong She
For about 25% of them, the dosage has to go up, and for about 5%, their energy level actually goes up too high and into a potentially harmful level. So testing is really the key to keep, or to get the energy optimized and keep the energy level in the optimal zone. That's absolutely essential. We started our work on developing led tests because testing for NAD is actually very difficult. And we have been the only company that can test led for patients and consumers for the last five years. And we have accumulated tremendous amount of data and we have defined what's the optimum level and what are the best ways to get any and optimize. You know, you mentioned the. You know, Nadiv and I, we have done clinical trials and what we have shown is that NAD actually does not increase any levels inside the cells. And that doesn't mean that Nadib does not provide any benefit. It does provide some temporary relief. And even though the NAD molecule is too big and cannot get inside the cells, they are receptors for NAD. On neuronal cells and on some immune cells, NAD combine the protein receptors and change the function of the neuronal cells.
[00:13:42.850] - Dr. Jin-Xiong She
That's why NadiV has been primarily used for treating certain neurological conditions, especially addictions. And that's through extracellular NAD. But it does not increase intracellular NAD. Over 90% of the function of NAD is related to intracellular NAD. So for anyone out there who is taking Nadiv will consider to getting Nadiv. My recommendation is you also need to use NAD precursors like NMN or NR to elevate and optimize your intracellular NAD to get the full benefit of the molecule.
[00:14:37.730] - Kayla Barnes-Lentz
So essentially the NAD IV, the molecules are a bit too big to be intracellular, but they can, you know, temporarily increase NAD extracellularly.
[00:14:51.220] - Dr. Jin-Xiong She
That's correct.
[00:14:52.370] - Kayla Barnes-Lentz
Got it. That's super helpful. And that. That's definitely been on my mind. And I've actually, you know, because I love testing things, right. So I love testing the Nadiv and now I'm doing, you know, your supplementation. And it's such a fun experience seeing what really moves the needle. So I did your test. I'm like on the low end of optimal, which, you know, it had been a few. It probably had been about a month because I moved and, you know, I was just having a bunch of things going on. So I hadn't done any d supplementation. So I was at the lower end of optimal. I've been doing your product now. Super excited to retest and get my levels up because at the end of the day, I just want the truth of what's going to work best so I can help share that with people and I can save them time and energy and resources of trialing all of these things on their own.
[00:15:45.760] - Dr. Jin-Xiong She
Yeah, I mean, in that case, my recommendation is, you know, unless you have certain neurological conditions, addictions or some infectious disease like Lyme's disease, and even long term COVID can potentially benefit from Nadiv. If you are just trying to get more energy, get yourself optimized. So I've been battling infection for the last couple of days.
[00:16:17.560] - Kayla Barnes-Lentz
That's okay.
[00:16:18.890] - Dr. Jin-Xiong She
And my recommendation is, you know, get on a good wall. NAD precursor. Both NMN and NR work. My preference is NMN because NMN is a one step precursor, is closer to NAD, and also NMN has some biological functions that NR doesn't seem to have. So overall, NMN has more functions, even though both can elevate NAD levels. So get a good early depreciation supplement. And, you know, I certainly recommend my product because our most products out there are just pure NMN or NR. And ours is a formulation with four ingredients that work synergistically to provide better elevation of LED. And more importantly, it revitalizes the cell function better than just NMN. And, you know, give it a try. And we actually provide guarantee. If it doesn't work for someone, we are happy to give the money back. And, you know, we are here to provide the benefits to people who want to work with us.
[00:17:53.170] - Kayla Barnes-Lentz
I love that. So what are the other ingredients? Can you talk about them? And maybe even. And just what are the benefits and how they work synergistically together?
[00:18:02.770] - Dr. Jin-Xiong She
So we have three main ingredients. We have creatine, male hydrate, or just creatine. And we have gin ribose, and we have nicotinamide. So, creatine, many people know creatine is a mouse builder, and that's absolutely true. And what most people don't know is that creatine is actually a battery for ATP. And you combine creatine and ATP, you make another molecule called phosphorylation or phosphor creating. All right? When you are not doing any kind of physical work and your body is still producing ATP, and that extra ATP can be stored in creating. And then you go exercise, you are going to play tennis, maybe some kind of rocket sports that can extend your lifespan by, you know, six to ten more years, you are going to get the energy quick and release of energy. That's when the force for creating, when release the ATP, and to give yourselves special muscle cells the energy to move around. So that's a very important point that many people don't know or don't understand. The second point is really related to what you do. So what has recently been found is that creatine is actually a neurotransmitter. So it functions as a neurotransmitter to improve neuronal communication.
[00:20:02.230] - Dr. Jin-Xiong She
And NAD is also a neurotransmitter. So what? Here we are providing two neurotransmitters in this formula. So that's why a lot of people have improved mental clarity and dramatically reduced brain fog. And that's because the led and creating are both functioning with neurotransmitters. And dean rivals is very important because nitrile is a component of not only the nucleic acid, but it's also part of the NAD molecule. If you combine the fourth ingredient, we have nicotinamide. With D ribose, you make nicotinamide riboside or nr. So here we actually have three different ways for your cells to make NAD, not just one. So we have NAD, we have NR, and we have nicotinamide that can be converted into NAD three different ways. And we are providing functions not only from NAD, but from the individual ingredients. And they work together and we get unbelievable outcomes, sometimes even. It's beyond my imagination. So one very fascinating story we had is an 18 month old baby girl from Turkey. And this baby fell into a will, unfortunately, and she went to a coma for six months. Her doctors tried everything and couldn't wake her up. The only thing she was able to do was to move her eyes for six months.
[00:22:00.890] - Dr. Jin-Xiong She
After trying everything, the doctor who has been working with us put her on the product. And after, after a few days, she started moving after a few weeks, and she actually walks again like a normal baby.
[00:22:16.610] - Kayla Barnes-Lentz
Wow, that's amazing.
[00:22:20.950] - Dr. Jin-Xiong She
I received the email about two months ago. Initially, I couldn't understand why that was happening, but after, afterwards I was thinking about it. I think what has happened is not only the products now is improving the neuronal communication, but also is increasing the neuromuscular communication. So, you know, in a coma, it's near the brain is not communicating with the muscles. You cannot wake up. Right. So it actually does make a lot of sense.
[00:22:58.840] - Kayla Barnes-Lentz
Wow, that's amazing. So what, you, you have a PhD, so what made you so interested in studying NAD in this way?
[00:23:09.920] - Dr. Jin-Xiong She
Well, my, my entire scientific career over 40 years has always been about identification of risk factors for diseases and prevention of diseases. My children came back so about now, probably six, seven years ago, I became very interested in longevity because, you know, I was not getting younger and I wanted to. Some of my high school and college classmates are already kind of falling apart, getting, getting very old. I decided that I'm not going to. I didn't want to fall into that trap and I wanted to change my course of direction and try to do something about it. And I believe that my knowledge and my skills can come up with some ways that can extend our health span. I'm not really about extending the maximum lifespan and I, even if you read my website, what I talk about is I want to close the gap between lifespan and health span. Lifespan is basically the life expectancy. It means average lifespan is life expectancy, right. And health spend is the number of years that we stay free of major diseases. Net gap is huge. We don't know exactly how many years, but is certainly between 20 to 30 years, if not more.
[00:25:37.320] - Dr. Jin-Xiong She
And my goal is to close this gap. I want as many people as possible to live to their life expectancy, healthy, active, and they can pursue what they are capable of doing. And that would be a huge achievement for me personally and scientifically. So I started looking into solutions about how to do it. And what I came up is a philosophical understanding, world realization. And that's actually based on the way I mentioned the chinese philosophy called Taoism. And now that applies perfectly here, because if you want to live healthy longer, you really have to find the balance and the harmony between your genes and your environment or lifestyle. So if you can keep this in a harmonious state, you are going to extend your health span. And the way that we can do it is through a program that we call the Tau Tao and let's test, act and optimize. Test is the fundamental part of the Tau program and why it's important to test. As many people can understand, test allows us to identify the deficiencies or abnormalities. Test allows us to identify the weakest links that each one has. And more importantly, test allows us to figure out whether anything that we do is efficacious.
[00:27:47.860] - Dr. Jin-Xiong She
It's actually working, it's making a difference or not. In many cases, the actions that people take not only are not making a difference, but in some cases, and actually in too many cases are potentially causing harms because they don't know what they really need. They don't know how much to take. Either they are now taking enough or they are taking too much. So testing will allow us to answer all these important questions, and testing allows us to come up with a customized and precision action plan. That's what I want to do. I mean, we not only test for NAD, we want to test reasonable number for biomarkers. It's very difficult to test, you know, hundreds and or thousands of biomarkers. Some people will do it. Brian Johnson probably testing a lot more. But I wanted to come up with a reasonable number of biomarkers that can give us an overall assessment of where we are and where we want to go. And we came up with about 22 biomarkers that we have in our panel. NAD stands out clearly at the very top, if not at the most important, because it's involved in pretty much every single cellular processes that's important to health.
[00:29:29.340] - Dr. Jin-Xiong She
And then later on, we realized that optimization of led makes everything else we do work so much better. So NAD optimization is the first and necessary step towards extending health span. Some people may argue that NAd may not extend lifespan. That depends on your point of view. If you ask, no one argues about extending health span. If you extend the health span, you are going to extend the lifespan. What the argument has been about is, it should be about, does it extend the maximum lifespan? We don't know what our maximum lifespan anyways. So arguing that point is, is pointless, in my view. At this particular point of time, we know we can live to 127, at least. That's the oldest person that has ever lived, I believe, and I'm very happy if I can give 220 healthy and do all the kind of things I can do. That's all I want for this moment.
[00:30:50.910] - Kayla Barnes-Lentz
I love that you talked about genetics. What impact do you think genetics have on longevity?
[00:30:59.910] - Dr. Jin-Xiong She
The common view of the impact with genetics on longevity is contributes about 10% of longevity. I think that's a oversimplification. On average, that may be true, but it's so variable from person to person. And in some individuals, if you inherit longevity genes, I think you're certainly going to live, well, at least highest opportunity to live much longer than from feminists without the longevity genesis. It also depends on how you define longevity genes. This is such year defined term. You know, people want to give a number, experts like David Sinclair and many, many others, they want to throw a number out there, and they want people to believe that that's the truth. That, I think is way oversimplified. For some individuals, genetics may determine maybe everything. If someone has a knife threatening gene to terminate their knife very early on. Genetics is everything, right? And for others, it's primarily environmental factors or lifestyles. And I think to emphasize the importance of lifestyle, because it's a choice that we can make that we can change. Unfortunately, we still cannot change our genes easily. Maybe one day we can do it. We already have the tools, and it's not widely applied yet.
[00:33:06.440] - Dr. Jin-Xiong She
And we will be able to change a lot of single genes, both better. So, because we cannot change our genes easily. And what we should focus on is how we can control our lifestyle for the better, for not to increase lifespan and health span. And from that point of view, downplaying genetics a little bit is probably appropriate.
[00:33:41.540] - Kayla Barnes-Lentz
Yes, I agree. So how do we measure NAD. What is the measurement and what are you looking for? Like, what are the optimal ranges? I'm sure that they may change based on. Or you can talk about, are there differences in sexes? Do women need more NAD or men need more nad?
[00:34:03.810] - Dr. Jin-Xiong She
Sure. First, the only test that genefinity offers is dried blood spot test. So you basically prick your finger and get one or two drops of blood on newborn screening card called a field paper, and you send it back to our lab in Georgia, and we do tending results within one week. And the result will tell you whether you are defeating or not and how difficult you are. And you can, even before you get the results, you can start supplementation because most people are likely deficient. Now, the, how do we define the optimum range is critical. We defined the optimum range based on two sets of data we have. The first one is what are the unity levels we see in young people? We will believe that younger people have higher unity level, which is true. And we believe most of them should be in some kind of optimum range, but it's not necessarily true. Okay. For example, if you take a vitamin D, I mean, children are deficient in vitamin D as well. So, defining optimum range based on data in younger people is how normally the reference range is defined. There are two ways to.
[00:36:02.030] - Dr. Jin-Xiong She
Three ways to define the optimum range. One is what you see in a normal population, so called healthy population. But there's no healthy population, frankly, and we will have some kind of issues. But that's how most medical tests are defined. It's called reference range. It's not called optimum range. Okay? There's a huge difference. And the second way to define is what you see in younger population if the neighbors change with age and energy certainly goes down with age. So defining the neighbors based on what you see in young people is actually a very good starting point. So what we, what we have seen is over 75% of the teenagers have led levels above 40 micromolar. We defined the lower range of the optimum range at 40. That's why it turns out that after taking energy supplements, we see health benefits in individuals who got energy level over 40 micromoles. So at what level you start seeing health benefits, and what we see in 75% of young people both put the lower end of the optimum range at about 40, you know, plus minus, you know, one never going to know exactly what's the, you know, what's the exact volume.
[00:38:11.200] - Dr. Jin-Xiong She
So we, we recommend that people should get their immediate, at least above 40. The ideal range is between 50 to 75 and we are defining the optimal range at between 41 hundred, but ideal is 50 to 75.
[00:38:34.540] - Kayla Barnes-Lentz
And is that the same for females and males?
[00:38:43.680] - Dr. Jin-Xiong She
We do not really know whether it should be the same or not. I am not, I do not see the difference between males and females in terms of the natural levels of NAD and I do not see a difference in terms of benefits when we get the NAD levels elevated. So I don't think. I don't think there's a difference. But at least I do not have enough data to define the difference between males and females in a meaningful way. I'm not saying absolutely there's no difference, but I don't think the difference is meaningful or we need to pay much attention to it. What I do see is a major difference between some ethnic groups. We see more severe energy deficiencies in Asians, especially Vietnamese, Koreans, indian and to some degree chinese relative to Caucasians. But it turns out that it's actually easier to get optimized in agents. I don't know.
[00:40:22.640] - Kayla Barnes-Lentz
Why would you. Why do you think that it's lower?
[00:40:27.970] - Dr. Jin-Xiong She
I do not really know. Recently what I realized is there is potentially a difference in the supplement called niacin. Niacin is also only the precursor. I think in western countries some food does contain niacin and niacin is probably more commonly supplemented in ethnicity american diet. So niacin can actually increase naD. But I don't recommend using niacin to increase NAD levels because it has some harmful effects.
[00:41:18.550] - Kayla Barnes-Lentz
You know what would be so interesting to do is I'm not sure if you have any data on pregnant women, but I do. You do? So what happens? Because I'm in family planning stages, it would be so much, it would be so interesting to benchmark each month or a couple of times a month and see what happens. Do any levels drop? Do they rise? Do they recover?
[00:41:47.450] - Dr. Jin-Xiong She
I don't have that type of data. So the data that I have is very interesting that I think we need to pay more attention to is probably oxidative stress free radicals. And during pregnancy the levels of oxidative stress just increased tremendously. And I think Imad should be prenatal vitamin, frankly. And that's going to be a very difficult fight because people are more cautious during pregnancy. I mean, and there's really no harm with any supplements. I think it's going to provide so much more benefit to both the mom and the unborn child if the imaging level is optimized before and during pregnancy, obviously after as well. And the nazi prenatal not just prenatal supplement that's really going to help women during pregnancy is reduction of oxidative stress. I'm really interested in this infertility pregnancy issues and I have not really had the time or find the right vehicle to get some studies done. It's going to be fascinating. We're going to be able to help so many people.
[00:43:45.790] - Kayla Barnes-Lentz
I love that. Well, we'll definitely talk off podcast about getting a bunch of tests because it's so fascinating. It's like we don't have that much data on what's actually happening during pregnancy. So I intend on doing full panel blood biomarkers every week during pregnancy to see what changes. You know, there's, there's a lot of data around even biological age increasing during pregnancy. And all of this makes sense because you're literally creating a human being. I mean, of course this is going to be very taxing on your body.
[00:44:21.450] - Dr. Jin-Xiong She
Yeah, everything changes. I mean, let's get our whole panel done on you as well. I'm very interested in having the data.
[00:44:34.320] - Kayla Barnes-Lentz
Me too.
[00:44:35.680] - Dr. Jin-Xiong She
I think it's going to be fascinating.
[00:44:37.680] - Kayla Barnes-Lentz
I completely agree. I love that. Okay, so let's talk about optimization protocols here. So obviously it's always best to test, right?
[00:44:48.380] - Dr. Jin-Xiong She
Yeah.
[00:44:48.810] - Kayla Barnes-Lentz
But we can assume that most people are deficient in NAD. So if you can test, I'll certainly include a link. I've done the tests, I'll continue to be doing the test and sharing my data and just being very transparent about, you know, if, how it's going. But let's say that you don't have the resources to test, but you want to start NAD supplementation. What would be a reasonable starting protocol to optimize your levels?
[00:45:18.830] - Dr. Jin-Xiong She
Start with 1000 millivolts of NMN on a daily basis. And if, you know, for people who do not want to spend more money, you can get a pure NMN from us or from other companies. But, but don't, don't just go buy the cheapest product on Amazon. I mean there are, there are so many different brands and you don't want to just randomly buy and at least, you know, check the reputable companies. And if you are willing to spend a little more money, divide the boost that we have. Our website is the best NAd product and so we have both the pure NMN and the NMN formulation. And 95% of our customers choose the more expensive formulation over the cheaper pure NBN product because they know the difference. So you don't have to do a pretest test before supplementation. But I highly, highly recommend a test at least one test after supplementation. This way you know whether you are taking enough or whether you are taking too much. Too much is harmful. Punito does not provide you the benefits. So I would not save money on the testing after supplementation and also don't wait for too long to take a test.
[00:47:24.180] - Dr. Jin-Xiong She
Three to four weeks on the product daily, consistently, is enough to get your unity level up. If it doesn't go up after three to four weeks, continue to take the product the same way. The same amount will not increase your omnid level further.
[00:47:49.460] - Kayla Barnes-Lentz
Yeah. What are some. So we know age is obviously a risk factor for decreased NAD, but what are some other things that can increase NAD even if you're not of an older age?
[00:48:04.630] - Dr. Jin-Xiong She
Increase nad. What? Decrease NAD.
[00:48:06.410] - Kayla Barnes-Lentz
Sorry? Decrease NAD. Yeah, decrease nad levels.
[00:48:11.350] - Dr. Jin-Xiong She
There are many things that can decrease NAD, primarily inflammation. Inflammation increases a molecule called CT 38. That's nad degrading enzyme. If you are exposed to radiation toxins, that can damage damaged DNA and that will increase the activity of the enzyme that repairs damaged DNA and that requires NAD, can degrade NAD. And people with health conditions, diseases tend to have lower NAD levels because they need more energy to get their body to function more properly. So it's more related to health issues in a more significant way.
[00:49:05.160] - Kayla Barnes-Lentz
Yeah, that makes a lot of sense. You mentioned the CD 38 inhibitors. Right. So what are some examples of those?
[00:49:17.140] - Dr. Jin-Xiong She
Quercetin is a very common and relatively potent inhibitor of CD 38. There's another one that is under cancer drug in clinical trial, but it's not available as a supplement. And quercetin is really the only one epigrammed. But epigenin is not very actually recommended dose. Epigraming does not inhibit CD 30 a. So gene is the one that I would recommend, because carcinogen has a lot of other benefits. You can reduce inflammation, it can reduce uric acid, ua. And that's a major longevity biomarker.
[00:50:21.930] - Kayla Barnes-Lentz
So just for clarity, CD eight inhibitors are a good thing, right?
[00:50:27.410] - Dr. Jin-Xiong She
CD eight inhibitors are good to see. Yeah.
[00:50:29.750] - Kayla Barnes-Lentz
Okay. Yeah. So it's okay to do quercetin and NAD and Mn supplement?
[00:50:36.400] - Dr. Jin-Xiong She
I think everyone should take a quercetin, 1000 milligrams of quercetin as a routine supplement.
[00:50:42.480] - Kayla Barnes-Lentz
Daily.
[00:50:43.530] - Dr. Jin-Xiong She
Yeah, that's what I do. And quercetin is a synonytic compound. It reduces senescence burden.
[00:50:55.680] - Kayla Barnes-Lentz
What do you think? I've seen a few companies doing anti spinallytics. So you'll do a higher dose of quercetin like every other month. What do you think about that?
[00:51:10.580] - Dr. Jin-Xiong She
Um, I am. Well, I'm glad you didn't mention the company because otherwise I cannot talk about it. I mean getting into trouble by, by, by saying that.
[00:51:28.790] - Kayla Barnes-Lentz
All right, well we'll skip that.
[00:51:30.700] - Dr. Jin-Xiong She
I need to be, I need to be very careful because I work with so many, so many companies. I advise them and I help them to develop a product. Sometimes I need to be careful and sure it's closing certain information. So now let me give you my channel belief or thinking. I prefer sinopreventive versus synonytics if it's possible. So I take daily quercetin at 1000 milligrams. I can add 500 milligrams of phytine as well. I also recommend at least 1000 milligrams of vitamin C and ideally probably 2000 milligrams of vitamin C because we know quercetin and vitamin C can synergize and increase their. I hate to call the synonymic function, but we can call it signal preventive function. And we have a senescence test. We know for many people if you take quercetin and vitamin C on a routine basis, we can bring down the senescence burden. That can work quite well in general. I don't like protocols that give very high doses and induce shocks to our body and then you cycle again and again. I'm more in prevention if you want. I mean that's my whole, my whole philosophy, right? We want to prevent bad things from happening instead of that happen.
[00:53:48.790] - Dr. Jin-Xiong She
And then I'm going to hammer it. That's not, that's not my, my philosophy.
[00:53:56.420] - Kayla Barnes-Lentz
I love that.
[00:53:58.580] - Dr. Jin-Xiong She
I don't know whether I'm right or wrong, but I think for most things I'm probably right. But it doesn't make sense why you want to hit your body with very high doses of anything. Like, you know, I was talking to a doctor this morning who was trying to get my advice, you know, for vitamin D, why give 50,000 units, sometimes even 100,000 units once every couple weeks or months, when you can do it daily? And you want, you want to maintain most nutrients on a constant basis. Not that it works up and down. That's usually not a good thing for your body. Take blood pressure, blood sugar levels. You don't want this to cycle back and up. You want it to be as flat as possible. And that, that I believe is also true for nutrients. You want it to be as consistent as possible.
[00:55:06.200] - Kayla Barnes-Lentz
Yeah, I mean, absolutely. I agree. Well, thank you for giving me your opinion on that. And I feel like this was so informative. Nad is so popular, right? Everyone is talking about Nad I am so excited I had the opportunity to talk with you about it, because obviously you have a wealth of knowledge, and I look forward to maybe doing some studies on women here soon with you.
[00:55:30.930] - Dr. Jin-Xiong She
Absolutely. It's my distinctive pleasure to talk to you, and I look forward to getting some studies of gland with you and your audience. That is going to be very interesting, and hopefully we can bring new solutions to people who want to solve some health issues and extend their health spend.
[00:55:59.590] - Kayla Barnes-Lentz
I love that. Well, I'm going to include links in the show notes for your tests, your products, your website, and there'll be some codes. So anyone listening, if you want to test your NAD levels, all the information will be below. If you want to optimize your NAD levels, this is the protocol I'm currently doing, so you can try it out, too.